Modification in adsorption properties of graphene during the development of viral biosensors
Eliseev I. A.1, Gushchina E. A. 1, Klotchenko S. A. 2, Lebedev A. A. 1, Lebedeva N. M. 1, Lebedev S. P. 1, Nashchekin A. V. 1, Petrov V. N. 1, Puzyk M. V.3, Roenkov A. D. 4, Smirnov A. N.1, Tanklevskaya E. M. 1, Usikov A. S. 4,5, Shabunina E. I.1, Schmidt N. M. 1
1Ioffe Institute, St. Petersburg, Russia
2Smorodintsev Research Institute of Influenza, St. Petersburg, Russia
3Herzen State Pedagogical University of Russia, St. Petersburg, Russia
4Nitride Crystals Group, St. Petersburg, Russia
5 ITMO University, St. Petersburg, Russia
Email: natalia.shmidt@mail.ioffe.ru

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The well-known effect of the local interaction between graphene and photoresist (LIGF) during the creation of biosensors is shown to lead to non-uniform distribution of compressive stresses, which deteriorates the adsorption properties of graphene, parameter reproducibility, and detecting ability of influenza B and SARS-Cov-2 biosensors. It is also shown that controlling the occurrence of LIGF areas on a graphene surface by atomic force microscopy or introducing a protective layer between graphene and photoresist can minimize the non-persistent effect of LIGF. The results of influenza B and SARS-CoV-2 imaging on the graphene surface in biosensor chips in a scanning electron microscope are presented. Keywords: graphene, biosensors, SARS-CoV-2, influenza virus B.
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