The aim of this study is to develop a carbon nanotube-based nanocomposite material that enables the restoration of the integrity of blood vessels damaged during anastomosis procedures, using laser irradiation without disrupting blood flow. In most cases, traditional methods for restoring the integrity of blood vessels such as sutures, adhesives, or electrocautery are inefficient, technically challenging, or may cause further damage to the surrounding tissues. The proposed approach, which combines laser biophotonics with nanomaterials science, enables treatment of vascular defects with diverse geometries, minimizes mechanical contact with biological tissues, and accelerates the healing and regeneration process of the damaged tissue. The core of the method is a nanocomposite material composed of: water; single-walled carbon nanotubes at a concentration of 0.001 to 0.1 wt.%; indocyanine green as a chromophore at a concentration of 0.01 wt.%; sodium cholate as a surfactant at a concentration of 0.004 wt.%; and proteins collagen and bovine serum albumin at concentrations of 12 wt.% and 25 wt.%, respectively. Under controlled laser irradiation with a wavelength of 810 nm and a maintained temperature of 57 ^oC, the carbon nanotubes interconnect to form a robust scaffold within the protein matrix. In vivo and in vitro experiments on porcine, bovine, and ovine aortas demonstrated the formation of a bond with a tensile strength exceeding 1.5 MPa, without disrupting blood flow, causing material leakage into surrounding healthy tissues, or inducing thrombosis. Keywords: laser surgery, blood vessels, biopolymers, single-wall carbon nanotubes.

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Дата начала обработки статистических данных - 27 января 2016 г.