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Development of equipment and techniques for magnetic resonance imaging of the lungs of laboratory animals with the use of hyperpolarized 129Xe
Fattakhov Ya. V.
1, Fakhrutdinov A. R.
1, Konovalov D. A.
1, Odivanov V. L.
1, Shagalov V. A.1, Bayazitov A.A.
1, Bashirov F. V.
2, Markosyan V. A.
2, Vodovozov V. M.3, Pavlenko A.V.3, Kurunov R.V.3, Baev V. M.3, Kuleshov M. V.3, Eremkin V. V.3, Baturina A. A.3, Sirko M. S.3
1Zavoisky Physical-Technical Institute, FRC Kazan Scientific Center of RAS, Kazan, Russia
2Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan, Russia
3D.V. Efremov Institute of Electrophysical Apparatus, St. Petersburg, Russia
2Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan, Russia
3D.V. Efremov Institute of Electrophysical Apparatus, St. Petersburg, Russia
Email: yfattakhov@yandex.ru, fakhrutdinov@kfti.knc.ru, dak@knc.ru, odivanov@mail.ru, vash@rambler.ru, alfisgdi5s5d@yandex.ru, faridbashirov@yandex.ru, vage.markosyan@gmail.com, vodovozov@sintez.niiefa.spb.su, pavlenko@sintez.niiefa.spb.su, kurunov@niiefa.spb.su, baev@sintez.niiefa.spb.su, kuleshov@sintez.niiefa.spb.su, eryomkin@sintez.niiefa.spb.su, baturina@sintez.niiefa.spb.su, sirko@sintez.niiefa.spb.su
A method for NMR imaging of the lungs of laboratory animals with the use of hyperpolarized (HP) 129Xe was validated. A setup for producing HP 129Xe was designed. A magnetic resonance imaging system was modified for operation with xenon nuclei, and an apparatus for controlling the breathing of laboratory animals was designed and manufactured. A tracheostomy procedure needed to maintain the breathing of laboratory animals in the course of lung imaging was validated. An experiment on imaging of the lungs of laboratory animals with the use of HP 129Xe was carried out. Keywords: magnetic resonance imaging, hyperpolarized 129Xe, artificial lung ventilation, laboratory animals.
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