Production of gadolinium nanoparticles in a polymer matrix by a pulsed mechanical impact
Aleksandrov A. I.1, Zezin S. B.2, Abramchuk. S. S.3
1Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow, Russia
2Lomonosov Moscow State University, Moscow, Russia
3A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia
Email: alivaleksandr@mail.ru
In this study, superparamagnetic elemental-gadolinium nanoparticles 2 to 12 nm in size were for the first time obtained under a pulsed mechanical impact (rheological discharge explosion). The synthesis was carried out in one stage in an environmentally friendly ("green chemistry") mode in a polymer matrix doped with the Gd(QH)3 complex, where QH is a ligand based on 3,6 di-tert-butyl phenol that is an environmentally safe antioxidant. Emergence of these particles was confirmed by electron paramagnetic resonance, X-ray phase analysis and transmission electron microscopy. This synthesis may be a regarded as basis for further progress in producing gadolinium nanoparticles which can be used in neutron- and photon-capture therapy of malignant neoplasms with biological targeting using magnetic resonance imaging or computed tomography. Keywords: gadolinium, nanoparticle, mechanical impact, neutron- and photon-capture therapy, malignant neoplasms.
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