Photooxidation of tetrahydrobiopterin as the basis of vitiligo phototherapy
TeleginaT. A. 1,2, Vechtomova Yu. L. 1, Kritsky M. S. 1, Nizamutdinov A. S.3, Madirov E. I. 2,3, Makarova D.A. 3, Buglak A. A. 2
1A. N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia
2St. Petersburg State University, St. Petersburg, Russia
3Kazan Federal University, Kazan, Tatarstan, Russia
Email: telegina.43@mail.ru, vechtomova@inbi.ras.ru, mkritsky@inbi.ras.ru, anizamutdinov@mail.ru, ed.madirov@gmail.com, makarovadaryaaa@mail.ru, andreybuglak@gmail.com

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The kinetics of photooxidation of tetrahydrobiopterin was investigated, the quantum yields of the formation of dihydropterin dimers were calculated when using a xenon lamp, a tunable UV laser and a UV LED as UV radiation sources. A comparative analysis of the effectiveness of these sources for the photooxidation process of tetrahydrobiopterin allowed us to conclude that the most effective for the purposes of vitiligo phototherapy are, apparently, UV LED sources with emission maxima in the region of 325 nm. Keywords: vitiligo, tetrahydrobiopterin, melanin, oxidative stress, H2O2, UVB vitiligo phototherapy.
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