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Powerful terahertz radiation source for studying the effects on protein conformation
Russian version
Teplyakov V. V.1, Cherkasova O. P. 2,3,1, Nazarov M. M.1, Konnikova M. R.1,4, Tverdislov V. A.4, Gotovtsev P. M.1
1National Research Center “Kurchatov Institute”, Moscow, Russia
2Institute of Automation and Electrometry, Siberian BranchRussian Academy of Sciences, Novosibirsk, Russia
3Institute of Laser Physics of the Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
4Moscow State University, Moscow, Russia
Email: tepliakov.vv17@physics.msu.ru, o.p.cherkasova@gmail.com, nazarovmax@mail.ru, konnikovamaria@gmail.com, tverdislov@mail.ru, gotovtsevpm@gmail.com
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The effect of terahertz pulses with an energy of 10 μJ, a peak field of 1.3 MV/cm, and a spectrum from 1 to 6 THz on protein (bovine serum albumin) was investigated. The protein pre-pressed into a pellet was irradiated. The exposure time was 15 min. After irradiation, the protein was dissolved in water at a concentration of 1 mg/mL. UV spectroscopy in the range of 220-360 nm revealed a decrease in the molar extinction coefficient, which can be interpreted as a sign of structural changes in protein molecules under irradiation with terahertz radiation with the specified parameters. Keywords: intensive terahertz radiation, effects, albumin, UV spectroscopy.
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