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Fluorescence spectroscopy of blood plasma and cerebrospinal fluid for the diagnosis of cerebral gliomas
Russian version
Nurgalieva P. K.1, Cherkasova O. P.2,3, Yakimov B. P.1,4, Stupak E. V.5, Glotov V.M.5, Stupak V. V.5, Shirshin E. A.1
1Lomonosov Moscow State University, Moscow, Russia
2Institute of Automation and Electrometry, Siberian BranchRussian Academy of Sciences, Novosibirsk, Russia
3Novosibirsk State Technical University, Novosibirsk, Russia
4Laboratory of Clinical Biophotonics, Scientific and Technical Park of Biomedicine, First Moscow State Medical University (Sechenov University), Moscow, Russia
5Novosibirsk Research Institute of Traumatology and Orthopedics n.a. Ya.L. Tsivyan, Novosibirsk, Russia
Email: nurgalieva.pk17@physics.msu.ru
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This study investigated the capabilities of fluorescence spectroscopy of blood plasma and cerebrospinal fluid in diagnosing cerebral gliomas. Key findings included a decreased ratio of tyrosine to tryptophan autofluorescence in the blood plasma of glioma patients compared to a control group with traumatic brain injuries. Furthermore, upon excitation at 320 nm, the plasma fluorescence spectra of Grade IV glioma patients exhibited a long-wavelength shift relative to lower-grade tumors. Additionally, analysis of cerebrospinal fluid fluorescence decay kinetics at 280 nm excitation successfully differentiated glioma patients from the control cohort. Keywords: autofluorescence spectroscopy, time resolved fluorescence spectroscopy, blood plasma, cerebrospinal fluid.
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