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Analysis of raman spectra during excitation at wavelengths 532 and 785 nm for rapid skin tumors diagnosis
Russian version
Saraeva I. N. 1, Rimskaya E. N.1, Gorevoy A. V. 1, Timurzieva A. B. 1,2, Shelygina S. N. 1, Perevedentseva E. V. 1, Kudryashov S. I 1
1Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia
2Federal State Budgetary Institution "National Research Institute of Public Health named after N.A. Semashko", Moscow, Russia
Email: saraevain@lebedev.ru, rimskaya@lebedev.ru, a.gorevoy@lebedev.ru, shelyginasn@lebedev.ru, kudryashovsi@lebedev.ru
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Raman microspectroscopy is an important method for skin cancer diagnosis in the early stages. The differentiation of malignant skin tumors (basal cell carcinomas of the skin, squamous cell carcinomas), benign skin tumors (papillomas) and healthy skin was carried out by acquiring Raman spectra in vitro with laser excitation at wavelengths of 532 and 785 nm and analyzing them using the principal component method. A comparison of the spectral features of the components with known peaks of molecular vibrations was carried out. It has been shown that differential diagnosis at an excitation wavelength of 785 nm is more reliable than at 532 nm, providing a probability of correct classification above 90%. The proposed methods can be applied for in vivo analysis for non-invasive rapid diagnostics using appropriate equipment for spectra registration. Keywords: skin tumors, confocal scanning Raman microspectroscopy, principal component analysis method.
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