Application of high-resolution terahertz spectroscopy to study the chemical composition of thermal decomposition products of bladder cancer tissues
Vaks V.L. 1,2, Anfertev V.A. 1, Domracheva E.G. 1,2, Chernyaeva M.B. 1,2, Atduev V.A. 3,4, Atduev K.A.3, Cherniaeva A.S.1
1IPM RAS, Nizhny Novgorod, Russia
2Lobachevsky State University, Nizhny Novgorod, Russia
3Privolzhsky District Medical Center of the Federal Medical and Biological Agency of Russia, Nizhny Novgorod, Russia
4Privolzhsky Research Medical University, Nizhny Novgorod, Russia
Email: elena@ipm.sci-nnov.ru, anfertev@ipmras.ru, elena@ipmras.ru, masha@ipm.sci-nnov.ru, atduev@mail.ru, atduev7777@gmail.com, aleksacherny@gmail.com

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Due to the need to detect oncological diseases at an earlier stage, when timely surgical or therapeutic treatment increases the likelihood of patient survival, it is urgent to search for and develop effective diagnostic and therapeutic strategies. Approaches based on metabolomics have the potential to identify sets of metabolite markers of cancer, which is important for early cancer recognition. One of the types of cancer that are difficult to detect in the early stages in modern conditions is urothelial cancer, for which the metabolic approach is promising in the early stages. The work is devoted to the study of the chemical composition of thermal decomposition products of primary metabolites for bladder tumor tissues, conducted for the first time using high-resolution THz spectroscopy methods. Keywords: bladder cancer, biological tissue, thermal decomposition products, metabolites, high-resolution THz spectroscopy.
  1. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum (International Agency for Research on Cancer, 2004), 83, 1-143
  2. S. Chavan, F. Bray, J. Lortet-Tieulent, M. Goodman, A. Jemal. Eur Urol., 66, 59-73 (2014). DOI: 10.1016/j.eururo.2013.10.001
  3. M. Burger, J.W.F. Catto, G. Dalbagni, H.B. Grossman, H. Herr et al. Eur Urol., 63, 234-241 (2013). DOI: 10.1016/j.eururo.2012.07.033
  4. C. Steinmaus, C. Ferreccio, J. Acevedo, Y. Yuan, J. Liaw et al. Cancer Epidemiol Biomarkers Prev., 23, 1529-1538 (2014). DOI: 10.1158/1055-9965.EPI-14-0059
  5. M. Tuccori, K.B. Filion, H. Yin, O.H. Yu, R.W. Platt, L. Azoulay. BMJ, 352, i1541 (2016). DOI: 10.1136/bmj.i1541
  6. K. Chrouser B. Leibovich, E. Bergstralh, H. Zincke, M. Blute, J. Urol., 174 (1), 107-110 (2005). DOI: 10.1097/01.ju.0000163459.57305.a1
  7. V.A. Moyer.Ann. Intern. Med., 155 (4), 246-51 (2011). DOI: 10.7326/0003-4819-155-4-201108160-00008
  8. M. Babjuk, M. Burger, O. Capoun, D. Cohen et al. Europ. Eur. Urol., 81 (1), 75-94 (2022). DOI: 10.1016/j.eururo.2021.08.010
  9. National Cancer Institute (NCI). SEER Cancer Stat Facts: Bladder Cancer, 2023. [Electronic source]. URL: https://seer.cancer.gov/statfacts/html/urinb.html
  10. Campbell-Walsh-Wein Urology, 12th Edition, ed. by A.J. Wein, T.F. Colon et al. (Elsevier, 2020)
  11. F.A. Yafi F Brimo, J. Steinberg, A.G. Aprikian, S. Tanguay, W. Kassouf. Urol. Oncol., 33 (66), e25 (2015). DOI: 10.1016/j.urolonc.2014.06.008
  12. V.B. Lokeshwar, T. Habuchi, H.B. Grossman, W.M. Murphy, S.H. Hautmann et al. Urology, 66, 35-63 (2005). DOI: 10.1016/j.urology.2005.08.064
  13. M. Ahangar, F. Mahjoubi, S.J. Mowla. Front. Oncol., 14, 1453278 (2024). DOI: 10.3389/fonc.2024.1453278
  14. M.G. Vander Heiden, L.C. Cantley, C.B. Thompson. Science, 324 (5930), 1029-1033 (2009). DOI: 10.1126/science.1160809
  15. Human Metabolome Database [Electronic source]. URL: www.hmdb.ca
  16. M. Llambrich, J. Brezmes, R. Cumeras. Biological Procedures Online, 24 (1), 20 (2022). DOI: 10.1186/s12575-022-00184-w
  17. F. Pereira, M.R. Domingues, R. Vitorino, I.M.S. Guerra, L.L. Santos, J.A. Ferreira, R. Ferreira. Int. J. Mol. Sci., 25, 3347 (2024). DOI: 10.3390/ijms25063347
  18. V. Vantaku, J. Dong, C.R. Ambati, D. Perera, S.R. Donepudi, C.S. Amara, V. Putluri, S.S. Ravi, M.J. Robertson, D.W.B. Piyarathna et al. Clin. Cancer Res., 25, 3689-3701 (2019). DOI: 10.1158/1078-0432.CCR-18-1515
  19. V. Vaks, E. Domracheva, M. Chernyaeva et al. J. Biophotonics, 18 (12), e202400316 (2024). DOI: 10.1002/jbio.202400316
  20. V. Vaks, E. Domracheva, M. Chernyaeva, V. Anfertev, A. Maslennikova, V. Atduev, K. Atduev, M. Rodionov.Appl. Sci., 14, 1955 (2024). DOI: 10.3390/app14051955
  21. V.L. Vaks, V.A. Anfertyev, V.Yu. Balakirev, S.A. Basov, E.G. Domracheva, A.V. Illuk, P.V. Kupriyanov, S.I. Pripolzin, and M.B. Chernyaeva. Phys. Usp., 63 (7), 708-720 (2020). DOI: 10.3367/UFNe.2019.07.038613
  22. V.L. Vaks, E.G. Domracheva, M.B. Chernyaeva, V.A. Anfertyev, A.A. Ayzenshtadt, and A.V. Maslennikova, V.A. Atduev. Teragerzevaya fotonika (300-year history of the Russian Academy of Sciences (RAS)) (RAS, M., 2023), p. 576-632 (in Russian)
  23. H.M. Pickett, E.A. Cohen, B.J. Drouin, J.C. Pearson et al. Submillimeter, Millimeter, and Microwave Spectral Line Catalog. JPL Molecular Spectroscopy (California Institute of Technology). http://spec.jpl.nasa.gov/ftp/pub/catalog/catform.html
  24. C.P. Endres, S. Schlemmer, P. Schilke, J. Stutzki, H.S.P. Muller. J. Mol. Spectrosc., 327, 95-104 (2016). https://cdms.astro.uni-koeln.de/cgi-bin/cdmssearch
  25. W. Gordy, R.L. Cook. Microwave molecular spectra (J. Wiley\&Sons, N.Y., 1984).
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