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Study of the influence of differentiation parameters on the characteristics of derivative electronic absorption spectra
Russian version
Shestopalova N. B. 1
1Saratov State Medical University named after V. I. Razumovsky, Saratov, Russia
Email: shestopalovanb@yandex.ru
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The article presents the results of a study of the characteristics of first- to fourth-order derivatives of papaverine hydrochloride absorption spectra obtained using scanning spectrophotometer software. Using the example of an asymmetric shortwave absorption band, the transformation of zero-order spectra upon differentiation with various Δλ intervals from 1 to 80 nm is graphically demonstrated. The influence of the specified parameters (scanning step and differentiation interval) on the shape of the derivatives is assessed. It is established that with increasing Δλ, the curve shapes, positions of extrema, and "zero crossings" change. The obtained results can be used to develop methods for the identification and quantification of individual compounds and the analysis of multicomponent systems. The use of the spectrophotometer software allows for the rapid and reliable selection of optimal scanning parameters and differentiation of absorption spectra. Keywords: absorption spectra, differentiation, derivative spectrophotometry, papaverine hydrochloride.
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