Modern biophotonics methods as a powerful practice on dosage regime determination illustrated by endovascular administration of polymer microcapsules during targeted delivery
Gusliakova O. I.1,2, Prikhozhdenko E. S.2, Plastun V. O.2, Mayorova O. A.2, Shushunova N. A.2, Kulikov O. A.3, Abdurashitov A. S.1, Gorin D. A.4, Sukhorukov G. B.1,5, Sindeeva O. A.1
1Vladimir Zelman Center for Neurobiology and Neurorehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia
2Scientific Medical Center, Saratov State University, Saratov, Russia
3Institute of Medicine, National Research Mordovian State University named after Ogarev, Saransk, Russia
4Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, Moscow, Russian Federation
5Life Improvement by Future Technologies Сenter, Skolkovo, Moscow, Russia
Email: O.Gusliakova@skoltech.ru, O.Sindeeva@skoltech.ru
Rational selection of dosage regimen is the key to the future success of the therapeutic effectiveness of new therapeutic formulation. Modern visualization systems make it possible to in situ evaluate the effectiveness of selected parameters for carriers administrated into a living organism and make reasonable adjustments. In an effort to maximize the accumulation of drug delivery systems in the target organ during targeted delivery, one should not forget about maintaining normal physiological processes. The strategy of tandem use of imaging systems that evaluate the biodistribution of a certain fluorescent label and the state of individual organs or systems can speed up and simplify the process of selecting methods for conducting in vivo experiments. This article shows how assessing the biodistribution of a fluorescent conjugate associated with microcapsules using fluorescence tomography helps determine a dosage regimen for intra-arterial administration that ensures effective accumulation of carriers in the target mouse kidney, and a laser speckle-contrast imaging system allows us to eliminate dosages leading to the development of pathological conditions in the target organ. Keywords: fluorescence, intravital imaging, biodistribution, laser speckle contrast imaging, microcapsules.
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