Pronina E. V.
1, Kremennaya M. A.
1, Lysenko V. Y.
1, Yalovega G. E.
11Faculty of Physics, Southern Federal University, Rostov-on-Don, Russia
Email: epronina@sfedu.ru, kremennaya@sfedu.ru, vlysenko@sfedu.ru, yalovega@sfedu.ru
The contributions of additional Fe-binding sites and heme iron to the experimental spectrum of urea-influenced hemoglobin were evaluated based on theoretical analysis of X-ray absorption spectra. The theoretical Fe K-edge X-ray absorption spectra were calculated for structural models of the supposed additional Fe binding sites and heme. Linear combination fit of theoretical spectra showed that in treated hemoglobin iron ions are more likely to be in the additional Fe-binding sites, which is surrounded by the following amino acids: cysteine-93, histidine-146, and asparagine-94 (Cys 93, His 146, Asp 94). Keywords: hemoglobin, XANES, additional iron-binding sites, endogenous toxicants.
- S. Reeg, T. Grune. Antioxid. Redox Signal., 23 (3), 239 (2015). DOI: 10.1089/ars.2014.6062
- J.S. Cristovao, B.J. Henriques, C.M. Gomes. Protein Misfolding Diseases. Methods in Molecular Biology (Humana New York, N.Y., 2019), 1873, p. 3-18. DOI: 10.1007/978-1-4939-8820-4
- D. Motz, S. Praetz, C. Schlesiger, J. Henniges, F. Bottcher, B. Hesse, H. Castillo-Michel, S. Mijatz, W. Malzer, B. Kanngieb er, C. Vogt. J. Anal. At. Spectrom., 38 (2), 391 (2023). DOI: 10.1039/D2JA00351A
- G.E. Yalovega, M.A. Kremennaya. Crystallogr. Rep., 65 (6), 813 (2020). DOI:10.1134/S1063774520060395
- N.N. Novikova, M.V. Kovalchuk, E.A. Yurieva, O.V. Konovalov, N.D. Stepina, A.V. Rogachev, G.E. Yalovega, O.V. Kosmachevskaya, A.F. Topunov, S.N. Yakunin. J. Phys. Chem. B, 123 (40), 8370 (2019). DOI: 10.1021/acs.jpcb.9b06571
- O.V. Konovalov, N.N. Novikova, M.V. Kovalchuk, G.E. Yalovega, A.F. Topunov, O.V. Kosmachevskaya, E.A. Yurieva, A.V. Rogachev, A.L. Trigub, M.A. Kremennaya, V.I. Borshchevskiy, D.D. Vakhrameev, S.N. Yakunin. Materials, 13 (20), 4635 (2020). DOI: 10.3390/ma13204635
- PDB-Protein Data Bank. http://www.rcsb.org/
- Y. Joly. Phys. Rev. B, 63 (12), 125120 (2001). DOI: 10.1103/PhysRevB.63.125120
- N.N. Novikova, S.N. Yakunin, M.V. Kovalchuk, E.A. Yuryeva, N.D. Stepina, A.V. Rogachev, M.A. Kremennaya, G O.E. Yalovega, O.V. Kosmachevskaya, A.F. Topunov. Crystallografiya, 64 (6), 931 (2019) (in Russian). DOI: 10.1134/S0023476119060134
- K.B. Shumaev, O.V. Kosmachevskaya, A.A. Timoshin, A.F. Vanin, A.F. Topunov. Methods in Enzymology. Globins and Other Nitric Oxide-Reactive Proteins, Part A (Academic Press, 2008), 436, p. 445-461 DOI: 10.1016/S0076-6879(08)36025-X
- M. Padjasek, A. Kocy a, K. Kluska, O. Kerber, J.B. Tran, A. Kr ezel. J. Inorg. Biochem., 204, 110955 (2020). DOI: 10.1016/j.jinorgbio.2019.110955
- S.M. Ireland, A.C. Martin. Database, 2019, baz006 (2019). DOI: 10.1093/database/baz006
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