Influence of the duration of circadian rhythm dis-turbance by light exposure on the morphology of the liver of laboratory rats
Pakhomy S. S.
1, Zlobina O. V.
1, Bugaeva I. O.
1, Maslyakova G. N.
1, Ivanov A. N.
1, Moskvina A.O.
11Saratov State Medical University named after V. I. Razumovsky, Saratov, Russia
Email: spakhomy03@gmail.com, zlobinaow@mail.ru, bugaeva@sgmu.ru, gmaslyakova@yandex.ru, lex558452@rambler.ru, aleksa590@yandex.ru
We studied the effect of long-term constant light exposure on the severity and reversibility of morphological changes in the liver of laboratory rats. Modeling of light exposure was carried out by means of 24-hour exposure to artificial light (in the daytime - 300 lk, at night - 500 lk). During the study we found that morphological changes in the liver were represented by damage to the parenchyma and circulatory disorders, the degree of which increased with increasing duration of exposure. After providing natural light in the laboratory, gradual recovery of the morphological structure of the organ was observed, which indicates the reversibility of the changes detected. Keywords: light exposure, circadian rhythms, morphology, liver.
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