Оптика и спектроскопия

Авторам

Правила оформления публикаций

Вышедшие номера

2024
- 1 2 3 4 5 6 7 8 9
2023
- 1 2 3 4 5 6 7 8 9 10 11 12
2022
- 1 2 3 4 5 6 7 8 9 10 11 12
2021
- 1 2 3 4 5 6 7 8 9 10 11 12
2020
- 1 2 3 4 5 6 7 8 9 10 11 12
2019
- 1 2 3 4 5 6 7 8 9 10 11 12
2018
- 1 2 3 4 5 6 7 8 9 10 11 12

Solid lipid curcumin-loaded particles for in vivo fluorescent imaging in humans: a proof of concept^*

DOI: 10.21883/OS.2019.06.47776.56-19

Переводная версия: 10.1134/S0030400X19060067

Российский научный фонд, 17-75-10215

Gogoleva M.A.¹, Yakimov B.P.¹, Rodionov S.A. ², Tikhonova T.N.³, Gurfinkel Y.I.⁴, Fadeev V.V.¹, Lademann J.⁵, Darvin M.E.⁵, Shirshin E.A.¹

¹Lomonosov Moscow State University, Faculty of Physics, Moscow, Russia

²N.N. Priorov National Medical Research Center of Traumatology and Orthopedics, Moscow, Russia N.N. Priorov Central Institute for Traumatology and Orthopedics, Moscow, Russia

N.N. Priorov Central Institute for Traumatology and Orthopedics, Moscow, Russia

³International Laser Center, Lomonosov Moscow State University, Moscow, Russia

⁴Lomonosov Moscow State University Clinic, Moscow, Russia

⁵Charite --- Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Berlin, Germany Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Berlin, Germany

Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Berlin, Germany

Email: shirshin@lid.phys.msu.ru

Поступила в редакцию: 15 января 2019 г.

Выставление онлайн: 20 мая 2019 г.

PDF версия

Абстракт
Статистика просмотров

The possibility to use oral intake of fluorescent dyes approved on humans for intravital fluorescence in vivo imaging is attractive due to its simplicity and non-invasive character. Here we investigate the potential of solid lipid curcumin particles (SLCP) for imaging of capillary permeability using fluorescence video capillaroscopy. Curcumin fluorescence corresponding to 0.7 μg/ml concentration was observed from blood plasma after oral consumption of 2 g of SLCP. However, this signal was ~ 15% higher than that of blood plasma intrinsic fluorescence, which was itself at least 10-fold lower than the background signal from pericapillary tissue. By comparing the optical properties and concentration to the case of intravenous injection of sodium fluorescein, we analyzed which parameters of the experiment should be optimized for using oral consumption of fluorescing compounds in intravital in vivo capillaroscopy measurements. -19

Подсчитывается количество просмотров абстрактов ("html" на диаграммах) и полных версий статей ("pdf"). Просмотры с одинаковых IP-адресов засчитываются, если происходят с интервалом не менее 2-х часов.

Дата начала обработки статистических данных - 27 января 2016 г.

Учредители

Издатель