Вышедшие номера
Solid lipid curcumin-loaded particles for in vivo fluorescent imaging in humans: a proof of concept*
Переводная версия: 10.1134/S0030400X19060067
Российский научный фонд, 17-75-10215
Gogoleva M.A.1, Yakimov B.P.1, Rodionov S.A. 2, Tikhonova T.N.3, Gurfinkel Y.I.4, Fadeev V.V.1, Lademann J.5, Darvin M.E.5, Shirshin E.A.1
1Lomonosov Moscow State University, Faculty of Physics, Moscow, Russia
2N.N. Priorov National Medical Research Center of Traumatology and Orthopedics, Moscow, Russia
3International Laser Center, Lomonosov Moscow State University, Moscow, Russia
4Lomonosov Moscow State University Clinic, Moscow, Russia
5Charite --- Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Berlin, Germany
Email: shirshin@lid.phys.msu.ru
Поступила в редакцию: 15 января 2019 г.
Выставление онлайн: 20 мая 2019 г.

The possibility to use oral intake of fluorescent dyes approved on humans for intravital fluorescence in vivo imaging is attractive due to its simplicity and non-invasive character. Here we investigate the potential of solid lipid curcumin particles (SLCP) for imaging of capillary permeability using fluorescence video capillaroscopy. Curcumin fluorescence corresponding to 0.7 μg/ml concentration was observed from blood plasma after oral consumption of 2 g of SLCP. However, this signal was ~ 15% higher than that of blood plasma intrinsic fluorescence, which was itself at least 10-fold lower than the background signal from pericapillary tissue. By comparing the optical properties and concentration to the case of intravenous injection of sodium fluorescein, we analyzed which parameters of the experiment should be optimized for using oral consumption of fluorescing compounds in intravital in vivo capillaroscopy measurements. -19

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