Вышедшие номера
Advanced Nanotools for Imaging of Solid Tumors and Circulating and Disseminated Cancer Cells*
Переводная версия: 10.1134/S0030400X18110309
Russian science foundation, 17-15-01533
Sukhanova A. 1,2, Ramos-Gomes F. 3, Alves F. 3,4, Chames P. 5, Baty D.5, Nabiev I. 1,2
1Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia
2Laboratoire de Recherche en Nanosciences, LRN-EA, Ulniversite de Reims Champagne-Ardenne, Reims, France
3Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine, Gottingen, Germany
4Clinic of Haematology and Medical Oncology, University Medical Center Go ttingen, Gottingen, Germany
5Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche Contre le Cancer de Marseille (CRCM), Marseille, France
Email: alyona.sukhanova@univ-reims.fr, Ramos@em.mpg.de, falves@gwdg.de, patrick.chames@inserm.fr, daniel.baty@inserm.fr, igor.nabiev@univ-reims.fr
Поступила в редакцию: 6 июля 2018 г.
Выставление онлайн: 20 октября 2018 г.

Semiconductor quantum dots (QDs) are characterized by orders of magnitude higher multiphoton linear absorption cross-sections compared with conventional organic dyes. Combined with the QD photoluminescence quantum yield approaching 100% and their rock-solid photostability, this fact opens great prospects for the two-photon functional tumor imaging with QDs tagged with highly specific recognition molecules. Single-domain antibodies (sdAbs) or "nanobodies" derived from lamas are the smallest high-affinity recognition molecules, which may be tagged with the QDs thus permitting not only solid tumors multiphoton imaging but also rare disseminated cancer cells and micrometastases in the depth of the tissue to be detected. -18

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