Study on the effect of low-temperature atmospheric pressure plasma jet on the morphofunctional properties of living tissues (in vivo)
Giraev K. M. 1,2, Ashurbekov N. A. 1, Israpov E. Kh. 1,2, Shakhsinov G. Sh. 1, Abdulaev V. R.1, Rabadanov K. M. 1, Isaeva Z. M. 1
1Dagestan State University, Makhachkala, Dagestan Republic, Russia
2Amirkhanov Institute of Physics, Daghestan Federal Research Center, Russian Academy of Sciences, Makhachkala, Russia
Email: kamal_giraev@mail.ru, nashurb@mail.ru, gadz@bk.ru, kurbanbagama91@mail.ru

PDF
The results of spectral-fluorescent and diffuse-optical studies of living tissues under the effect of low-temperature atmospheric pressure plasma jet in a mixture of air and argon are presented. Potential fluorophores are identified and coefficients of optical absorption and transport scattering of tissues are determined. It was revealed plasma jet irradiation of tissue leads to an increase in the intensity of fluorescence and the diffuse reflection coefficient, which is linked with a twofold increase in the transport scattering coefficient and a change in the concentration of endogenous chromophores - a reducing water content, lipids and bilirubin to 20%, and an increasing levels of oxygen saturation to 10%. On the basis of the analysis, it is shown that the therapeutic effect of low-temperature plasma can be associated with increased antioxidant protection and the development of compensatory dehydration processes. Keywords: biological tissues, cold plasma, probing, spectroscopy, fluorescence, diffuse reflection, optical coefficients, light scattering, biochemistry, morphology.
  1. A. Stancampiano, D. Forgione, E. Simoncelli, R. Laurita, R. Tonini, M. Gherardi, V. Colombo. J. Adhesive Dentistry, 21 (3), 229 (2019)
  2. A. Mariachiara, A. Venturuzzo, A. Gelmetti, E. Guasco, S. Bassissi, M. Rossi, P. Calzavara-Pinton. Clinical Plasma Medicine, 19-20, 100110 (2020). DOI: 10.1016/j.cpme.2020.100110
  3. Th. Bernhardt, M. Semmler, M. Schafer, S. Bekeschus, S. Emmert, L. Boeckmann. Oxidative Medicine and Cellular Longevity, 2019, 3873928 (2019). DOI: 10.1155/2019/3873928
  4. E.A. Golubitskaya, O.S. Troitskaya, E.V. Yelak, P.P. Gugin, V.A. Richter, I.V. Schweigert, D.E. Zakrevsky, O.A. Koval. Acta Natura, 11 (3), 16 (2019)
  5. E. Sysolyatina, M. Vasiliev, M. Kurnaeva, I. Kornienko, O. Petrov, V. Fortov, A. Gintsburg, E. Petersen, S. Ermolaeva. J. Phys. D., 49, 294002 (2016)
  6. N.Y. Babaeva, G.V. Naidis. Trends in Biotechnology, 36 (6), 603 (2018)
  7. K. Kletschkus, N. Gelbrich, M. Burchardt, A. Kramer, S. Bekeschus, M. Stope. Health Physics, 119 (1), 153 (2020)
  8. D. Xu, Q. Cui, Y. Xu, Zh. Liu, Z. Chen, W. Xia, H. Zhang, D. Liu, H. Chen, M. Kong. AIP Advances, 8 (10), 105219-1 (2018). DOI: 10.1063/1.5046353
  9. I. Trizio, E. Sardella, V. Rizzi, G. Dilecce, P. Cosma, M. Schmidt, T. Woedtke, R. Gristina, P. Favia. Plasma Medicine, 6 (1), 13 (2016)
  10. X. Sua, Y. Tianb, H. Zhoua, Y. Lib, Zh. Zhanga, B. Jianga, B. Yanga, J. Zhang, J. Fang. Appl. Environ. Microbiol., 84 (9), e02836-17 (2018). DOI: 10.1128/AEM.02836-17
  11. F. Saadati, H. Mahdikia, H.-A. Abbaszadeh, M.-A. Abdollahifar, M. Khoramgah, B. Shokri. Scientific Reports, 8 (1), 7689 (2018). DOI: 10.1038/s41598-018-25990-9
  12. A. Akbiyik, D. Sari, U.K. Ercan, Y. Uyanikgil, H. Tasli, C. Tomruk, Y.H. Usta. J. Appl. Microbiol., 131 (2), 973 (2020)
  13. K.V. Pozhar, M.O. Mikhailov, E.A. Polyakova, E.L. Litinskaia, Yu.E. Abolemova. Biomedical Engineering, 55 (2), 84 (2021)
  14. V.D. Genin, A.B. Bucharskaya, E.A. Genina, G.S. Terentyuk, N.G. Khlebtsov, V.V. Tuchin, A.N. Bashkatov. In: Proc. of SPIE, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine (SPIE, USA, 2020), Vol. 118450. DOI: 10.1117/12.2590422
  15. X. He, D. Hu, X. Fu, X. Rao. Postharvest Biol. Technol., 179, 111570 (2021). DOI: 10.1016/j.postharvbio.2021.111570
  16. V.V. Tuchin, J. Popp, V. Zakharov. Multimodal Optical Diagnostics of Cancer. (Springer Nature Switzerland AG, Switzerland, 2020). DOI: 10.1007/978-3-030-44594-2
  17. J.H. Lam, K.J. Tu, S. Kim. Biomed. Opt. Expr., 12 (6), 3091 (2021)
  18. F. Ghasemi, P. Parvin, N. Sadat, H. Motlagh, S. Abachi. Biomed. Opt. Expr., 8 (2), 512 (2017)
  19. E. Tsibulskaya, N. Maslov. J. Chemometrics, 35 (6), e3343 (2021)
  20. A.A. Moghaddam, B. Sajad, F.M. Nia, S.H. Madani. J. Lasers Med. Sci., 12, e10 (2021). DOI: 10.34172/jlms.2021.10
  21. S.L. Jacques. Phys. Med. Biol., 58 (11), 37 (2013)
  22. A.J. Welch, M.J.C. Van Gemert. Optical-Thermal Response of Laser Irradiation Tissues, 2nd ed. (Springer Science+Business Media, Luxembourg, 2011). DOI: 10.1007/978-90-481-8831-4
  23. V.V. Tuchin. Optika biologicheskikh tkanei. Metody rasseyaniya sveta v meditsinskoy diagnostike, 2nd issue (Fizmatlit, M., 2013) (in Russian)
  24. S.A. Prahl. PhotochemCAD [Electronic source]. URL: http://omlc.ogi.edu/spectra/PhotochemCAD/html/index.html
  25. B. Bandi. Metody optimizatsii, ed. by V.A. Volynsky. (Radio i svyaz, M., 1988) (in Russian)
  26. K.M. Giraev, K.S. Bekshokov. N.A. Ashurbekov, N.M. Abdullaeva, E.Kh. Israpov. Opt. Spectr., 122 (4), 632 (2017)
  27. J.R. Lakowicz. Principles of Fluorescence Spectroscopy, 3rd ed. (Springer Science+Business Media, Luxembourg, 2006). DOI: 10.1007/978-0-387-46312-4
  28. A.C. Croce, A. Ferrigno, G. Bottiroli, M. Vairetti. Liver International, 38, 1160 (2018)
  29. D. Nelson, M. Cox. Lehninger Principles of Biochemistry. (Laboratoriya znanij, M., 2020), Volume 2
  30. G.T. Hanson, R. Aggeler, D. Oglesbee. J. Biol. Chem., 279, 13044 (2004)
  31. I.E. Hassinen. J. Innovative Optical Health Sci., 7, 1350058-6 (2014)
  32. R. Carmona, S. Barrena, R. Munoz-Chapuli. J. Dev. Biol., 7 (2), 10 (2019)
  33. A. Hohn, T. Grune. Redox Biology, 1, 140 (2013). DOI: doi.org/10.1016/j.redox.2013.01.006
  34. S. Bayati, R. Yazdanparast. Iran Biomed J., 15 (4), 134 (2011)
  35. A.N. Bashkatov, E.A. Genina, M.D. Kozintseva, V.I. Kocubei, S.Yu. Gorodkov, V.V. Tuchin. Opt. i spektr., 120 (1), 6 (2016) (in Russian)
  36. A.N. Bashkatov, E.A. Genina, V. Kochubei. Kvant. elektron., 44, 779 (2014) (in Russian)
  37. O.D. Myadelets. Gistologiya, tsitologiya i embriologiya cheloveka. (VGMU, Vitebsk, 2016) (in Russian)
  38. B. Beauvoit, M. Kimura, B. Chance. Biophys. J., 67, 2501 (1994)
  39. J.M. Schmitt, G. Kumar. Appl. Opt., 37, 2788 (1998)
  40. B. Halliwell, J.M.C. Gutteridge. Free Radicals in Biology and Medicine. (Oxford University Press, Great Britain, 2015). DOI:10.1093/acprof:oso/9780198717478.001.0001

Подсчитывается количество просмотров абстрактов ("html" на диаграммах) и полных версий статей ("pdf"). Просмотры с одинаковых IP-адресов засчитываются, если происходят с интервалом не менее 2-х часов.

Дата начала обработки статистических данных - 27 января 2016 г.

Publisher:

Ioffe Institute

Institute Officers:

Director: Sergei V. Ivanov

Contact us:

26 Polytekhnicheskaya, Saint Petersburg 194021, Russian Federation
Fax: +7 (812) 297 1017
Phone: +7 (812) 297 2245
E-mail: post@mail.ioffe.ru