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Detection of single biomolecules using a solid-state nanopore SiN/Si sensor
Vaulin N. V.
1, Afonicheva P. K.2, Lebedev D. V.1,2, Bukatin A. S.1,2, Mukhin I. S.1,3, Evstrapov A. A.2
1Alferov Federal State Budgetary Institution of Higher Education and Science Saint Petersburg National Research Academic University of the Russian Academy of Sciences, St. Petersburg, Russia
2Institute for Analytical Instrumentation of the Russian Academy of Sciences, Saint Petersburg, Russia
3Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, Russia
2Institute for Analytical Instrumentation of the Russian Academy of Sciences, Saint Petersburg, Russia
3Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, Russia
Email: nikitavaylin@mail.ru
Developed a technique for immobilizing single molecules of the 26S proteasome in the region of a solid-state SiN nanopore under the action of an applied electric field. The process of immobilization of a single molecule of the 26S proteasome leads to a change in the ion current through the nanopore by 20%. Further development of this technique may allow highly efficient immobilization of single biomolecules in order to study their conformational activity. Keywords: Nanopore, solid-state nanopore, nanopore sensor, single molecule detection, 26S proteasome.
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Подсчитывается количество просмотров абстрактов ("html" на диаграммах) и полных версий статей ("pdf"). Просмотры с одинаковых IP-адресов засчитываются, если происходят с интервалом не менее 2-х часов.
Дата начала обработки статистических данных - 27 января 2016 г.